Curve Biosciences, spun out of Stanford, develops blood tests that map cell-free DNA methylation patterns back to the organ they came from, extending liquid biopsy techniques from cancer into chronic disease monitoring.
Curve Biosciences's first products track the progression of liver conditions such as MASH and cirrhosis, aiming to catch dangerous transitions early using a simple blood draw rather than biopsy or imaging.
Methylation patterns carry a return address. Because cell-free DNA in the blood can be traced back to the organ it came from, the techniques built for early cancer detection also work for chronic disease, and the far larger population living with liver conditions can be monitored from a single tube of blood.
NZVC invested in Curve Biosciences from NZVC Fund I. We file the company under Bio and Healthcare on the portfolio wall.
We backed Curve because the science that made early cancer detection possible can now monitor the far larger population living with chronic disease, and Curve has built one of the most detailed tissue methylation atlases to do it. The founding team carries deep experience from Natera and GRAIL, where they helped build the blood tests that defined the category. Chronic disease monitoring is a vast market with poor existing tools, and the timing fits a broad shift toward earlier, less invasive care.